Oxysterol-binding protein-related protein 3b

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August undefined, 2024

WebApr 10, 2024 · Lipid transfer proteins in the Sec14 and oxysterol-binding protein (OSBP)-related protein (ORP) families, which have well-defined lids to their hydrophobic cavities and bind phospholipids tail-first [14, 47], similarly exhibit conformational changes upon membrane binding that displace the lids to their hydrophobic cavities as required for lipid ... WebID: OSBL1_MOUSE DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 1; Short=ORP-1; Short=OSBP-related protein 1; FUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional …

Fungal oxysterol-binding protein-related proteins promote …

WebFeb 14, 2024 · Oxysterols accumulate in tissues and exert pharmacologic effects on cellular sterol biosynthesis and uptake. They are oxidized byproducts of cholesterol that cause cytotoxic effects on a variety of cells. Oxysterol-binding proteins such as OSBP1 ( 167040) and OSBP2 may mediate oxysterol cytotoxicity in tissues (summary by Moreira et al., … WebThe oxysterol-binding protein-related proteins (Orp) are conserved from yeast to humans and are implicated in the regulation of sterol homeostasis and in signal transduction … lake wenatchee fish species

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As part of the Lipid Transfer proteins (LTPs) family, ORPs have different and variate functions. This functions include signaling, vesicular trafficking, lipid metabolism and nonvesicular sterol transport. ORPs have been studied in many organisms cells as human cells or yeast. In yeast, where organelle membranes are closely apposed it has been proposed that ORPs work as sterol transporter… Web32 minutes ago · Among the 42 identified proteins (Fig. 1B–I, Supplementary Fig. 2, Supplementary Tables 1–3, and Supplementary Movie 1), approximately half are … WebMar 1, 2009 · It binds to oxysterol-binding protein-related protein 3B [62], which is also upregulated in the mutants and is proposed to cycle between the ER and the Golgi [62]. … hell\\u0027s storm

Structure–Activity Relationships of Ligand Binding to Oxysterol-Binding …

The targeting of the oxysterol-binding protein ORP3a to

WebMay 17, 2024 · Oxysterol-binding protein-like 2 (OSBPL2), also known as oxysterol-binding protein-related protein (ORP) 2, is a member of lipid transfer protein well-known for its … WebJun 24, 2024 · Lipids must be correctly transported within the cell to the right place at the right time in order to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer proteins (LTPs), which contain a hydrophobic cavity that sequesters lipid molecules. Oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of … hell\\u0027s super mark cainWebApr 13, 2024 · Sterols are present in eukaryotic membranes and significantly affect membrane fluidity, permeability, and microdomain formation. They are synthesized in the endoplasmic reticulum (ER) and transported to other organelles and the plasma membrane. Sterols play important roles in the biogenesis and maintenance of mitochondrial … lake wenatchee snowshoe trails

"WebMar 14, 2024 · Abstract. Oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) have emerged as potentially druggable targets in antiviral and precision cancer … " - Oxysterol-binding protein-related protein 3b

Oxysterol-binding protein-related protein 3b

Entry - *606731 - OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 2; …

WebJan 5, 2024 · ORP3A; OSBP (OXYSTEROL BINDING PROTEIN)-RELATED PROTEIN 3A; T7H20.150; T7H20_150; UNFERTILIZED EMBRYO SAC 18 Summary Encodes a protein that binds to beta-sitosterol and localizes to the ER. The WFDE motif in ORP3a appears to be important for a direct interaction with PVA12 [Plant VAMP-Associated protein 12]. WebThe OSBP-related protein family Protein families displaying sequence homology to the carboxy-terminal sterol-binding domain of oxysterol-binding protein (OSBP; denoted OSBP-related ligand-binding domain [ORD]) are present in practically all eukaryotic organisms [1]. In humans [2,3], as well as in mice [4], the gene

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http://cjbmb.bjmu.edu.cn/EN/10.13865/j.cnki.cjbmb.2024.08.03 WebLOC103859303 oxysterol-binding protein-related protein 3B [ (field mustard)] Gene ID: 103859303, updated on 22-Aug-2024. Summary Other designations. oxysterol-binding …

Several structural features and functional domains have been identified within the … 1.. IntroductionOxysterol-binding protein (OSBP) is a high-affinity receptor protein … In contrast to fungal and mammalian cells, where oxysterol-binding proteins are … The hyd1 mutant is phenotypically similar to fk (Figure 2) and was predicted to be … Analyses of deletion mutants of OSBP revealed that the carboxy-terminal half of … Proteins with sequence homology to the carboxy-terminal ligand binding domain … Cellulose is the major load-bearing and omnipresent polysaccharide in the … Sterol was the name originally proposed to describe a 3β-monohydroxy compound … Kes1p shares homology with human oxysterol binding protein and participates … The isolation of a gene from Saccharomyces cerevisiae, SWH1, with a … WebMay 17, 2024 · Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin Oxysterol-binding protein-like 2 contributes to the developmental progression of preadipocytes by binding to β-catenin Cell Death Discov. 2024 May 17;7 (1):109. doi: 10.1038/s41420-021-00503-2. Authors

WebApr 6, 2024 · The blue fluorescent protein (BFP) was cloned from the pLVX-BFP plasmid. The PH domain of oxysterol-binding protein (OSBP) and human heat shock protein family A member 5 (HSPA5) gene were cloned from the THP-1-cell cDNA library. ... (Figure 3b). HSPA5 is a member of the heat shock protein 70 (HSP70) family and localizes to the ER … WebMar 3, 2024 · Author summary Membrane contact sites (MCSs) between the two largest cellular membranes, the endoplasmic reticulum (ER) and the plasma membrane (PM), are regulatory interfaces for lipid synthesis and bidirectional transport. The yeast Osh protein family, which represents the seven yeast oxysterol-binding protein related proteins …

WebAug 1, 2007 · Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity Article Dec 2024 Meng-Meng Chen Si-Ru Yang Jian Wang Jun Fan View Show abstract...

hell\\u0027s stone whiskyWebFeb 17, 2024 · Oxysterol-binding protein (OSBP)–related proteins (ORPs) have emerged as key mediators of nonvesicular lipid transport 10,11 and metabolism of phosphoinositides. 12,13 Among ORPs, ORP4 is expressed constitutively in the brain, heart, and testis, but is virtually absent from other human and murine tissues. ORP4-knockout mice exhibit … lake wenatchee fire infoWebGene ID: 820086, updated on 5-Jan-2024. Summary Other designations. OSBP(oxysterol binding protein)-related protein 3B lake wenatchee cabins for saleWebAug 3, 2024 · Abstract Oxysterol-binding protein (OSBP) is a non-vesicular transport protein that exists and participates in the metabolism of lipids and sterols in eukaryotic cells. OSBP is known as the oxysterol-binding protein-related protein (ORP) in mammals and oxysterol-binding protein homologues (OSH) in yeasts. lake wenatchee cabins for rentWebApr 29, 2015 · By whole-exome sequencing in 25 affected members of the family, they identified heterozygosity for a 2-bp deletion (c.153_154delCT; 606731.0001) corresponding to codons 51/52 in exon 3 of the OSBPL2 gene. They also studied 26 unaffected members of the family and found that the mutation segregated completely with the disorder. lake wenatchee rec clubWeb3.5 Sterol-transfer protein, Osh4. The oxysterol-binding protein-related proteins (Orp) are conserved from yeast to humans and are implicated in the regulation of sterol … hell\u0027s super mark cainWebFirst, oxysterol-binding protein like protein 3 (OSBPL3), the closest gene to rs10282247, encodes oxysterol-binding-related protein (ORP) 3 that serves as lipid transporters and manages cellular lipid metabolism. ... and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B. Cancer Sci. 2024;111(7) ... hell\\u0027s t1